Summary:

A scathing parodic dictionary, wherein how words are normatively and conventionally defined is replaced by what they often actually do mean. One of the many classic examples is Bierce's definition of "Bigot" as 'One who is obstinately and zealously attached to an opinion that you do not entertain.'

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This is the meticulously researched and beautifully constructed catalogue for a 1999 exhibition at the Duke University Museum of Art. Over one hundred items originally produced to serve the science of medicine were culled from the history of medicine collections in four North Carolina institutions: Duke, East Carolina University, University of North Carolina at Chapel Hill, and Wake Forest.

Covering a wide range of time periods, media, and nationalities, the exhibit was coordinated by Suzanne Porter, librarian and curator of the History of Medicine Collections at Duke University Library, and Julie Hansen, an art historian. Martin Kemp, Professor of Art at the University of Oxford, supplies a foreword to the catalogue.

The rich and unusual yield of materials is grouped thematically rather than chronologically in five sections: "Art and Anatomy," "The Surgical Arts," "The Doctor's Practice," "Obstetrics and Gynecology," and "Non-Western Medicine." All images and objects are accompanied by historical information, biographical detail, thoughtful analysis, and precise description.

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Simon Dykes is a successful artist about to open another big show of his work in London. A week before the opening, he goes out to a bar with his colleagues, indulges in drugs, has sex with his girlfriend, and falls into an uncomfortable sleep with bizarre dreams. He wakes up in a world where every person is a chimpanzee and where humans are kept in zoos or are experimented on in labs, and the few humans surviving in the wild are close to extinction.

Terrified and dismayed, he is taken to a psychiatric ward where the chimpanzee doctors try to help him overcome his "delusions" that he is actually a human. They eventually turn to Dr. Zack Busner, an alpha male, theoretical renegade and media star, as well as a maverick drug researcher, "anti-psychiatrist," psychoanalyst, and clinical psychologist. Together they try to understand the root of Simon's delusion and return Simon to his sanity and "chimpunity."

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Margaret returns one afternoon from tennis to discover that Lewis, her husband, has committed suicide by taking an overdose of pain medication. Lewis had been bedridden from amyotrophic lateral sclerosis (ALS). They had thoroughly discussed his plan to kill himself before he was unable to do so, but Margaret is surprised when it happens because she expected Lewis to leave her a message. There is none.

As Margaret prepares for her husband’s cremation, she recalls the circumstances under which he left his teaching job--not because of the ALS, but because he used to teach human evolution in his high school biology class, without giving "equal weight" to creationism.

Because this upset many of his students’ parents and local clergy, the principal several times suggested that Lewis might at least give a nod to creationism. However, Lewis, an outspoken opponent of religion, was insulted by this proposal and quit his job.

The undertaker encourages Margaret to hold a wake--to comfort her and their many friends--but she insists that Lewis wanted no wake and no service. The next day the undertaker brings her Lewis’ ashes; she goes out into the country at night and disperses them.

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This book contains 29 short essays by physician-scientist Lewis Thomas, originally published in the early 1970s in The New England Journal of Medicine. The essays center on science, and range in focus from the molecular (e.g., DNA) to the subcellular to the organism to social interactions and all the way up to the search for extra-terrestrial life. Some themes reappear in several essays: science as a grand, engaging enterprise worthy of the brightest minds; communication between organisms creating the intricate dance of the social organism; the relationship of man to both nature and the grand scheme of the universe.

Lewis is fascinated by communication not only at the cellular level, but also at the pheremonal and cerebral level: "Language, once it comes alive, behaves like an active, motile organism" (90). The ant and its colony, as an example of a simultaneous individual and integrated social organism, form a link for Thomas between the enclosed unit of a cell and the complex interactions of a society. Indeed, macro-micro comparisons continue throughout the essays, and even conclude the final essay, "The World's Biggest Membrane," which lauds the atmosphere as protector, filter, and provider: "Taken all in all, the sky is a miraculous achievement. It works, and for what it is designed to accomplish it is as infallible as anything in nature. . . it is far and away the grandest product of collaboration in all of nature" (48).

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Among animals only humans have difficulty giving birth. While other primates deliver their babies with little fuss, women experience painful labor and childbirth. The explanation for this discrepancy lies in the size of the human head at birth. As hominids evolved ever larger and larger brains, the fetal head had to increase in size at birth. Eventually the head almost outstripped the female pelvis's ability to expand enough to allow it through the birth canal. This delicate balance between fetus and pelvis accounts for human fetal and maternal morbidity and mortality.

As a response to the growing threat of childbirth, human females evolved away from estrus (i.e. sexual receptivity only when ovulating) to the menstrual cycle and continuous sexual receptivity. The mysterious moon-related cycle led women to formulate the concept of "time" and make the connection between sex and pregnancy. It also allowed them to refuse sex when they were ovulating.

Women then taught time consciousness to men, and men used their growing self-consciousness to begin to establish control over nature (and women). The sense of being-in-time led inevitably to awareness of mortality. This, in turn, stimulated humans to create gods and religion in order to ward off death anxiety.

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This selection of Miroslav Holub's poems is organized around five major topics--genealogy, anthropology, semiology, pathology, and tautology--rather than chronologically. The poems, some of which date back to his first collection in 1958, were translated into English by a number of different persons, but mostly by David Young, who has had a long-term collaboration with Holub.

Holub states his major preoccupation in "Bones," the very first poem in this collection: "We seek / a backbone / that will stay / straight." (p. 13) The search reaches its fullest expression in "Interferon," a long poem about messages, messengers, and interference: "Cells infected by a virus / send signals out . . .

And when a poet dies, deep in the night / a long black bird wakes up in the thicket / and sings for all it's worth." (p.159) The first step in the search is to learn to interpret the signals, and to understand the black bird's song. To do that, one has to ask questions. Yet, in the face of enormous "Suffering," we are drawn to passivity: "But I ask no questions, / no one asks any questions, / because it's all quite useless." (p. 147) How to overcome the inertia and proceed, even in the face of likely failure?

Holub reminds us that even "In the Microscope" we find "cells, fighters / who lay down their lives / for a song." (p. 149) In fact, there may be something worth fighting for, although perhaps we can only see it under extreme circumstances, as in "Crush Syndrome," where a concrete mixer snaps up the hand of a man cleaning it: "The finger bones / said a few things you don't hear very often...In that moment / I realized I had a soul." (p. 174). But perhaps what we call the soul is really just our deep yearning to survive, as in "Heart Transplant": "It's like a model of a battlefield / where Life and Spirit / have been fighting / and both have won." (p. 179)

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This book interweaves an American love story with the development and repercussions of x-ray technology and atomic energy. It is an intriguing and beautifully written story. The setting is the southeastern United States, where the male protagonist, Fos, meets and marries Opal. Fos is a returning World War I veteran when the story begins; the story ends some years after the atomic bomb is dropped in World War II.

Fos is stationed in France during World War I. His assignment is to produce chemical flares. He shares a trench bunker with "Flash," the regiment photographer. After the war is over, Fos and Flash open up a photography shop in Flash's hometown of Knoxville, Tennessee. Fos is fascinated by natural phenomena such as phosphorescence, radiation, and the application of scientific discoveries for practical use. Flash is a good businessman and has a way with the ladies.

After Fos marries Opal, the three are in business together--Opal has accounting experience and handles the shop's "books." On the side, Fos and Opal have a traveling show that features an "x-ray box" where people can view the skeleton of their own feet. Opal is part of the show, on exhibit to demonstrate how this works as Fos x-rays her feet. A baby comes into their lives--they name him Lightfoot. The novel takes these characters and a few other connected figures through the 1920s into the Depression of the 1930s and formation of the Tennessee Valley Authority, to the work on the atomic bomb at Oak Ridge National Laboratory. Fos is recruited by the government to work at Oak Ridge--to take photographs. To say any more about the plot would spoil the pleasure of reading this absorbing book.

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Martin Nanther is a member of the British House of Lords, having inherited his title from his great-grandfather, Henry. Physician to Queen Victoria, Henry specialized in hemophilia, the disease that Her Majesty was known to have passed to her son, Leopold, and other descendants. While the House of Lords considers a Bill to abolish hereditary peerage and Martin's much younger, second wife is obsessed with becoming pregnant, he escapes into his slow research for a biography of Henry

His patient genealogical investigations uncover deaths in infancy of several young boys in his own family, and Martin soon realizes that hemophilia (rather than the family's legendary tuberculosis) is the cause. Was that irony merely a coincidence? Or was hemophilia in his own lineage the impetus for his grandfather's research and position in life? And why was the disease hushed? Was it possible that his grandfather deliberately sought a bride with the trait in order to investigate it in his own progeny?

Martin soon finds himself wondering if this well-respected, medical man actually committed murder, or was he merely waylaid by unexpected love? Without giving too much away, suffice it to say that the answers prove so surprising and so disturbing, that Martin decides to abandon the biography of his ancestor, even as he learns that his inherited peerage has been revoked and that his next child will soon be born.

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This story of one exceptionally accomplished family's discovery of their past and future relationships with Huntington's Disease (HD) is also the story of how the Wexler family changed the cultural narrative of HD for other families at risk for this genetically-transmitted and currently incurable disease. The HD diagnosis of Leonore Wexler (the author's mother) inspires Milton Wexler, a psychologist, to create a major foundation for HD research, which develops critical mass and influence as Leonore Wexler's condition deteriorates, and after her death. The book interweaves the story of the Wexlers' emotional and other negotiations with HD and the story of their efforts to create an HD community comprised of those with active symptoms of HD, family members, advocates, and researchers.

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