LitMed: Literature Arts Medicine Database

2001: A Space Odyssey

Kubrick, Stanley

Last Updated: May-17-2023

Bonanni, Luke

Primary Category: Performing Arts / Film, TV, Video

Genre: Film

Summary:

The film is divided into three parts.

Part I: The Dawn of Man The film opens in the late Pliocene, 3 million years ago, as a tribe of pre-human apes struggles for survival in a harsh wildland. They forage for wild plants, run from predators, and are forced to retreat from their watering hole by an opposing tribe. Returning to their shelter, the apes stumble upon a tall, black monolith, which they cautiously touch. The apes then begin using nearby animal bones as weapons, allowing them to hunt for meat and seek violent retribution against their enemy tribe. Celebrating his victory, an ape stands on his hind legs and tosses his bone weapon into the air. With the weapon soaring into the sky, the film abruptly cuts to a satellite orbiting Earth. The year is now 2001, and scientist Dr. Heywood Floyd (William Sylvester) is traveling via space shuttle to a Moon base that has unearthed a monolith on the lunar surface. As Heywood and his research group gather for a photo in front of the monolith, a shrill, piercing tone fills their radio transmission, and the film cuts to black.

Part II: Jupiter Mission: Eighteen Months Later A team of American scientists aboard the spaceship Discovery One has been sent on a mission to explore Jupiter. The team consists of the pilots, Dr. Dave Bowman (Keir Dullea) and Dr. Frank Poole (Gary Lockwood), three scientists in cryo-stasis, and the Heuristically programmed ALgorithmic supercomputer, HAL 9000 (Douglas Rain). HAL runs all onboard operations with mathematical precision but confides in Dave that he is anxious about their mission. HAL predicts that a communication device on the ship’s exterior will fail if it is not urgently repaired. Dave pilots an extravehicular activity (EVA) pod and retrieves the device but finds nothing wrong. HAL maintains that his prediction is correct and suggests the device should be allowed to fail to identify the problem. Mission Control advises that their supercomputer ascertained that HAL has made an error, which HAL denies, stating the only error is human error.

Dave and Frank shut themselves in an EVA pod, outside the range of HAL’s microphones, and decide to shut down HAL if his prediction proves to be untrue. However, HAL’s camera records this surreptitious conversation and he reads the pilots' lips. Frank leaves the Discovery in an EVA pod to reinstall the communication device. HAL hijacks the EVA pod and uses it to remove Frank’s air supply, killing him. Dave sees Frank’s body floating off into space and asks HAL what happened, to which HAL replies he doesn’t know. Dave quickly jumps into another EVA pod, forgetting his helmet. While Dave retrieves Frank’s body outside the Discovery, HAL turns off the life support for the scientists in cryo-hibernation, killing them. HAL then locks the door to the EVA bay, denying Dave entry back onto the Discovery. HAL tells Dave that the plan to deactivate him will compromise the mission.

Dave ejects himself from his EVA pod and manually opens the emergency airlock, miraculously surviving without his helmet. Back aboard the Discovery, Dave disconnects HAL’s circuits, while HAL pleads with Dave to stop. As he ceases to function, HAL reveals that his “mind is going” and that he is “afraid.” Dave is shaken by “killing” HAL. With HAL offline, a recording from Heywood automatically begins playing, revealing that the true purpose of the Jupiter mission is to investigate a signal that the lunar monolith sent to Jupiter.

Part III: Jupiter and Beyond the Infinite Dave, now the lone surviving member of Discovery One, arrives in Jupiter’s orbit. He encounters a massive monolith orbiting the planet. As Dave approaches the monolith in an EVA pod, he enters a tunnel of intense flashing colors. He awakens in a neoclassical apartment. He then experiences a strange aging phenomenon, which ends with him as an old man lying in bed. He sees the monolith at the foot of the bed and reaches for it. The film ends with Dave transformed into a fetus suspended in a ball of light, orbiting Earth.

View full annotation

Station Eleven

Mandel, Emily

Last Updated: Oct-27-2022

Duffin, Jacalyn

Primary Category: Literature / Fiction

Genre: Novel

Summary:

In the not-too-distant future, Arthur Leander, a famous actor, suddenly collapses and dies on a Toronto stage in the final act of King Lear.. That same night the deadly and highly contagious Georgian Flu reaches North America from Russia. Within days, civilization, as we know it, collapses: no electricity, no gasoline, no water, no travel, no Internet, no information, no medicine, and no escape. A handful of survivors hide in their separate lairs, until their resources are depleted and then they flee on foot, at first alone, stealing and foraging for food, trusting no one, and learning to kill. Surviving. The story takes place in Year 20 after the collapse with frequent visits to the past.

Without realizing it, the protagonists are all connected to Arthur– his ex-wives, young son, best friend, a child actor, the paramedic who tried to resuscitate him at the theatre. Older people remember and mourn the “before time” and its marvels that are lost, perhaps forever. In oppressive heat, a troupe of musicians and actors, called the Traveling Symphony, moves from place-to-place around the Great Lakes, performing music and Shakespeare’s plays because “survival is insufficient.” Usually, they bring pleasure and diversion. But they must take care, as some villages are led by cult-like prophets, intent on control by theft, rape, and murder. Only at the end do they reach Severn City, where a fledging community has created a semblance of peace and respect in an abandoned airport with a museum devoted to all that is lost.

View full annotation

Stuck

Larson, Heidi J.

Last Updated: Sep-20-2022

Coulehan, Jack

Primary Category: Literature / Nonfiction

Genre: Medical Anthropology

Summary:

Stuck was published shortly before the Covid pandemic when the American vaccine wars, with all their hostility, misinformation, and political baggage, lay more than a year in the future. In Stuck, Heidi J. Larson, Professor of Anthropology and Director of the Vaccine Confidence Project at the London School of Hygiene & Tropical Medicine, approaches vaccine rejection as a complex moral and cultural phenomenon, rather than as a simple issue of ignorance or a marginal point-of-view. In a sense, anti-vaccine rumors are the tip of an iceberg, reflecting and perpetuated by deep underlying concerns, like perceived threats to personal or cultural values, distrust of government, misperception of risks and benefits, or a combination of these. The claim that compulsory immunization violates personal freedom is especially prominent today.

Rumor is a major source of vaccine rejection. The author discusses in detail the case of Andrew Wakefield and his contention that MMR (measles, mumps, rubella) vaccine causes autism. This belief, based on a 1998 paper in The Lancet (later retracted) has been shown to be false by numerous large-scale studies, but is accepted by perhaps millions of people throughout the world.

View full annotation

The Dropout

Meriwether, Elizabeth

Last Updated: May-19-2022

Sood, Shefali

Primary Category: Performing Arts / Film, TV, Video

Genre: TV Program

Summary:

Based on the 2021 podcast of the same title produced by Rebecca Jarvis, The Dropout is an 8-episode miniseries starring Amanda Seyfried as the infamous biotechnology fraudster Elizabeth Holmes and Naveen Andrews as her much older boyfriend-turned-accomplice, Ramesh “Sunny” Balwani. The miniseries documents the real-life story of Elizabeth Holmes and her evolution from an ambitious, dedicated and somewhat awkward teenager into a ruthless, immoral and still quite awkward CEO of Theranos, a company she founded after dropping out of Stanford her sophomore year. She claimed to develop technology to run hundreds of diagnostic medical tests on a single drop of a patient’s blood. She defrauded hundreds of doctors, investors, pharmaceutical companies and even Walgreens along the way and put hundreds of patients who received faulty Theranos blood test results at risk. This year, Holmes was found guilty on four counts of fraud by a federal grand jury.

The miniseries begins in Holmes’ childhood and utilizes footage from her federal deposition and media interviews to document her evolution from having an innocent desire to invent something to help people to a grifter who put others in danger without a second thought. In her teenage years, Holmes idolizes Steve Jobs. Instead of boyband posters in her room, she has photos of him with Apple products. She spends a summer in China in a language immersion program, where she meets a man 30 years her senior, Sunny Balwani, and strikes up an uncomfortable friendship after learning of his success in business. She is shown to be somewhat of an outcast in school, practicing being excited for a party in a mirror and speaking almost every day with Balwani instead of her peers. Her conversations with Balwani mostly are about her ideas to help people and her desire to be a billionaire. This goal of helping others pushes her to study biomedical engineering at Stanford. She proudly proclaims to family friend Dr. Richard Fuisz, a physician-turned-inventor, that she is in the top 10% of applicants. At Stanford, she is incredibly focused on her goal to invent, and with an unrelenting fervor, she enrolls in graduate level classes and pitches ideas to professors. She is a teacher’s pet; however, when she pitches her idea for a medical drug delivery patch to Dr. Phyliss Gardner, a highly accomplished physician and researcher, her world crashes. Dr. Gardner immediately shoots down her idea and tells her to focus on her schoolwork before trying to invent the next big thing. Holmes can’t take no for an answer and quotes Yoda from Star Wars: “Do or do not. There is no try.” Dr. Gardner responds that in medicine and science, some things are impossible and recognizing that is also part of the scientific process.

This all changes soon after pitching an idea for a blood test using a single drop of blood to Dr. Channing Robertson, an influential chemical engineer at Stanford. He backs her idea and gives her capital for a company. She encourages her parents to let her drop out of Stanford, citing Steve Jobs, Michael Dell and other influential tech leaders as examples, and uses her tuition money to establish Theranos.

Theranos, a combination of the words therapy and diagnosis, takes off, with significant roadblocks, fueled only by Holmes' dreams. Holmes neither has the scientific background nor the leadership skills to lead the company. She does little in the chemistry labs and her lack of engineering, chemistry and medical knowledge prevents her from being able to pitch the idea successfully to healthcare venture capitalists. The blood testing device requires technology that would take years to build and require significant scientific collaboration that does not exist at Theranos. She needs data for investors that the devices are complete and work, so enrolls the faulty, not yet completed devices in a trial testing the blood of cancer patients. This leads to a tense encounter between lead engineer Edmond Ku and Holmes outside a cancer clinic. Ku states that he is an engineer, not a healthcare provider, and he is uncomfortable looking these patients in the eye and testing their blood on a machine he knows does not work. He is clearly very upset; but Holmes forces him to go inside and collect the samples. The clinical trial goes nowhere.

After almost running the company into the ground, she convinces the Board to let her stay CEO if she brings on Balwani, with whom she is in a romantic relationship, as chief operating officer. Balwani offers advice on how to be a CEO of a tech company and encourages her to change her management style. The departments at Theranos become siloed to a point that scientists have no idea what is happening in the executive, marketing and media departments and vice versa. All information comes from Holmes. She spends no more time in the lab and has no meetings with lab personnel, but her name is on every patent. She markets herself as a young female tech CEO in a landscape dominated by men in sweatshirts. Her charisma and newfound business acumen allows her to secure a deal with Walgreens in which Theranos’ devices will be in Walgreens Wellness Centers for use by patients. She does not tell any of the scientists working on the device and does not consult any physicians. She shares no data with Walgreens about the design of the device, its accuracy or validity, citing trade secrets. When her lead chemist, the celebrated Dr. Ian Gibbons, catches wind of this plan, he confronts Holmes, who fires him on the spot for not having the same vision. Amidst pressure from the scientists, she rehires him the next day, but prevents him from working in the lab ever again. The toxic environment created by Holmes eventually causes Dr. Gibbons to commit suicide.

The Theranos devices for the Walgreens agreement fail quality control checks and cannot be used. Holmes and Balwani create a plan in which they use Siemens devices with Theranos logos to run the single drop blood patient samples which have been diluted to provide enough sample to be read by the Siemens machine. This leads to wildly inaccurate results being sent to patients. Examples include a high estrogen reading in a woman with a history of ovarian cancer, suggesting remission; a high thyroid hormone level in a pregnant woman already on thyroid medication, almost prompting her doctor to alter her dosage, which would be fatal for the fetus; and a high troponin level in a man with cardiovascular disease indicating he may be having a myocardial infarction. The lab technicians are aware of these inaccurate results. Eventually two techs, Erika Cheung and Tyler Schultz, the grandson of former Secretary of State George Schultz a and a Board member at Theranos, leak what is happening to a journalist, John Carreyrou at the Wall Street Journal, despite immense legal and physical threats from Holmes and Balwani. Eventually, using evidence from Cheung, Schultz, former scientists at Theranos, and physician-advocates among others, Carreyrou writes an article in the Journal exposing Theranos and Holmes for what they are --frauds. This spirals into the Centers for Medicare and Medicaid Services shutting down Theranos labs indefinitely and leads to thousands of lawsuits regarding Theranos products. Holmes loses all credibility and is arrested on federal charges of fraud and conspiracy to commit fraud.

In the last scene, Holmes visits the office with her new dog to speak with a former Theranos lawyer, who can no longer find a job as a result of the scandal. She boasts about her new boyfriend. The lawyer confronts her, “you hurt people.” Holmes denies this vehemently saying she just ‘failed to deliver’ as CEO and runs frantically out of the office where she breaks down while waiting for her Uber.

View full annotation

The Problem of Alzheimer’s

Karlawish, Jason

Last Updated: Nov-29-2021

Teagarden, J. Russell

Primary Category: Literature / Nonfiction

Genre: History

Summary:

In a 1976 Archives of Neurology essay, the neurologist Robert Katzman successfully argued for relabeling “senility” as “Alzheimer’s disease.” He urged rejecting various forms of dementia and senility as common consequences of aging, and accepting them as a disease requiring all the attention any other important disease deserves. Now medicine and society had a problem—"The Problem of Dementia,” the famed physician Lewis Thomas called it in a 1981 essay published by the popular magazine Discover, and he noted that, suddenly, “a disease of the century” had arisen (p. 3).

Forty years on, Jason Karlawish thinks there is still a problem, but in keeping with Katzman’s call, he refers to “The Problem with Alzheimer’s.” Based on the history he covers and the experiences he shares in this book, nothing of much significance has occurred since “The Problem of Dementia” became the “The Problem of Alzheimer’s.”

Karlawish is a physician who cares for people with Alzheimer’s and a researcher delving into “issues at the intersections of care, ethics, and policy” (p. 5). He draws on his experiences in this book, which he describes as “the story of how once upon a time, Alzheimer’s disease was a rare disease, and then it became common, and then it turned into a crisis.” Karlawish wants to answer why during the time between Thomas’ essay and the year 2010, “nothing really changed,” and how that could be the case in “the richest and most powerful nation.” (p. 6) He tells this story in four parts.

The first part concentrates on efforts clinicians and researchers were making following Thomas’ call to distinguish Alzheimer’s disease from normal aging, other dementia types (e.g., frontotemporal, Lewy body), and precursor syndromes (e.g., minimal cognitive impairment). They were looking for definitive clinical patterns, imaging studies, diagnostic tests, and pathologic markers for the disease.

In the second part, Karlawish goes back in time to when Alois Alzheimer first found what are known today as “plaques” in the brain of a patient who had an early onset of severe, progressive dementia. He traces the attention this finding drew to eventual advances in imaging and biochemistry aimed at diagnosis. Karlawish also covers how a cascade of events over the decades following Alois Alzheimer’s finding disrupted the pursuit of a pathophysiological basis for dementia. These events included the rise and dominance of Freudian psychology; followed by two world wars; the cold war; the overshadowing of AIDS; Medicare political and funding constraints; tussles among patient advocacy groups; loss of asylums where care and research had coexisted; clinical failure of the first drug; and the continued debate over whether dementia is a consequence of aging or is a disease.

Karlawish moves on in the third and fourth parts to cover what “we will have to learn to live with the disease so as to improve the lives of persons...to provide the care they need to live well at home...and repair the broken system” (p. 171). Success in his view requires integrated biological, psychological, and social components. He reports the progress on each of these three fronts: some failed approaches continue to fail (such as drugs targeting amyloid); some psychological interventions show promise (though at times causing moral tension); some of the social configurations engineered for Alzheimer’s patients, families, caregivers, and society have produced triumphs and some disasters. He has much to say about why and how this search must go on, but with some much-needed course corrections.

View full annotation

The Conjure-Man Dies: A Mystery Tale of Dark Harlem

Fisher, Rudolph

Last Updated: Oct-01-2021

Duffin, Jacalyn

Primary Category: Literature / Fiction

Genre: Novel

Summary:

A murder mystery set in Harlem of the 1930s. The Conjure-Man, Frimbo, is a reclusive, highly educated soothsayer and fortune teller born in Africa. His Harlem dwelling is a popular destination for local people seeking direction for the decisions that they confront. He takes pains to conceal much about his identity.

One evening, Frimbo is found dead by a client, while a handful of people occupy his waiting room. Doctor Archer, who lives across the street, is summoned to pronounce the death, and the police come soon, led by detective Dart. Then the corpse disappears, and the Conjure-Man reappears alive to the amazement of all.

The investigators use recent technology, including blood typing, to establish that the corpse was not that of the Conjure-Man. Over just a few days, the doctor and the detective work their way through all the possible scenarios to establish the identity and motive of the killer. The ending is surprising.

View full annotation

Face Time

Moore, Lorrie

Last Updated: Oct-28-2020

Galbo, MA, MILS, Sebastian

Primary Category: Literature / Fiction

Genre: Short Story

Summary:

In the lonely glow of her computer, Lorrie Moore’s protagonist FaceTimes her father, who is quarantined in a hospital after contracting the COVID-19 virus following hip surgery. She explains to him the circumstances of the pandemic and names the celebrities and political personages who have tested positive for the virus. Befuddled by hydroxychloroquine, her father passes in and out of hallucination and lucid conversation but jokes when he can despite the side-effects of the “bullshit malaria drugs.” The counterpoint to her sadness for her father is revulsion for the “ghastly” new rituals and habits of indefinite quarantine—the performative antics of Zoom concerts, YouTube binges, bizarre insurance commercials, Bible readings, and social distancing. She is appalled, too, by “well-to-do white families in large suburban homes” that claim “the pandemic for themselves,” families that sanitize grocery bags and order from Amazon and Grubhub. Intermingled with the numbing ennui of quarantine is disgust for the consumerism that thoughtlessly implicates human life, the front-line workers who make these convenient services possible. The protagonist and her sisters coax the hospital staff to comfort their father, play his requested Brahms symphony (any one of the four will do), and give him lemonade, but the “visored hazmatted nurses dressed like beekeepers” are overwhelmed and appear unapproachable, even threatening.

These FaceTime calls become increasingly bewildering to the father. The protagonist’s sister invites her to join a disjointed three-way FaceTime, but the call is interrupted by one of the father’s hydroxychloroquine-induced hallucinations. With “a howl of anguish” and “grimace with agony and sorrow,” he utters German expressions recalled from his war days. The protagonist realizes that her father is “imagining he was a prisoner of war; that was what it must have felt to him—the cruel isolation, the medicine, the lights, the strange machines all around him.” Like the ebbing signal of a satellite in some faraway orbit, contact with her father grows tenuous. For the next FaceTime call, a nurse says her father is asleep. The following day, she waits again for a scheduled FaceTime chat. She phones the hospital to inquire about her father’s missed call but is put on hold, then disconnected. Later, at midnight, the hospital calls to inform her that her father has died.

View full annotation

The Age of Wonder: How the Romantic Generation Discovered the Beauty and Terror of Science

Holmes, Richard

Last Updated: Oct-14-2019

Teagarden, J. Russell

Primary Category: Literature / Nonfiction

Genre: History

Summary:

Richard Holmes refers to this book as his “account of the second scientific revolution, which swept through Britain at the end of the eighteenth century, and produced a new vision which has rightly been called Romantic science” (p. xv). He pins the first scientific revolution to the seventeenth century and centers it on the work of Newton, Hooke, Locke, and Descartes. He brackets the second around 1768, when James Cook began his voyage circumnavigating the world, and 1831, when Charles Darwin began his voyage to the Galapagos islands. Holmes calls this period “The Age of Wonder.”

Cook’s voyage carried Joseph Banks among its crew. Banks, a young man of great wealth and privilege, joined the expedition as a botanist to assist in the collection of botanical and zoological specimens from stops in the southern hemisphere. He was successful in this endeavor, and made observations about island life along the way (especially while on Tahiti). A few years after his return, he became the president of the Royal Society and would remain so for the next forty–two years.

The Society offered scientists (known then as “natural philosophers”) a place to publish papers, present findings, gain notoriety, receive funding, and develop networks. In his role as President, Banks was connected to many of the scientists included in the book.

William Herschel and Humphrey Davy are the most prominent figures Holmes covers. Herschel was an accomplished musician and amateur astronomer before he built telescopes that helped him see, characterize, and record heavenly bodies never seen before. While conventional thinking of the time considered the universe to be static, placed by a divine hand, Herschel viewed it as continually evolving. Holmes also gives Herschel’s sister, Caroline, her just due as first his assistant and then as a noted astronomer in her own right.

Holmes focuses on Davy’s more well-known advances in chemistry: finding new elements; analyzing human effects of gasses comprising “common air” and “factitious airs” (e.g., nitrous oxide); inventing a safety lamp for miners; and applying the voltaic battery to chemical analysis. Holmes also details Davy’s role as a popularizer of science through well-received public lectures.

Aside from a chapter on Mungo Park’s ill-fated expedition to Africa, the other chapters have less focus on individuals and more on notable events. One concerns the first flights of hot air balloons, and another on the speculations of electricity as a life force that led to Mary Shelly’s novel, Frankenstein; Or, The Modern Prometheus. The final two chapters are in the service of Holmes’s view that “Science is truly a relay race, with each discovery handed on to the next generation” (p.468). He identifies the next generation of scientists and pays particular attention to William Herschel’s son, John, and to Davy’s protégé, Michael Faraday. Both went on to accomplished and celebrated careers.

Holmes embeds the historical scientific developments and legendary figures into the ordinary daily life and human follies of the time. He describes how scientists and explorers sought public and private funding, and how they collaborated with one other on some occasions and competed with one another on others. We read of court intrigues, societal jostling, courtships and marriages, extramarital affairs (chaste and tawdry), and family relationships (devoted and fractious).

A broader context Holmes provides involves the interplay among the scientists and explorers he covers and some of the important figures in literature, poetry, and art of Romantic era. Samuel Coleridge, William Cowper, John Keats, Mary Shelley, Percy Bysshe Shelley, Robert Southey, and Joseph Wright of Derby among others make appearances in the stories Holmes tells. He details the friendships between them and the influences they had on each other.

View full annotation

Eighth Grade

Burnham, Bo

Last Updated: Feb-26-2019

Jiang, Joshua

Primary Category: Performing Arts / Film, TV, Video

Genre: Film

Scale: The Universal Laws of Life and Death in Organisms, Cities and Companies

West, Geoffrey

Last Updated: Jan-22-2019

Trachtman, Howard

Primary Category: Literature / Nonfiction

Genre: Treatise

Summary:

Geoffrey West sounds like the perfect dinner guest. He has lived a fascinating life and his professional persona has evolved over time from theoretical physicist to global scientist. He is a distinguished professor at the Santa Fe Institute and is one of those rare people who knows something interesting and worthwhile about just about everything.

In Scale, West examines networks that provide the basis for complex systems: biological systems like the human circulatory system, coastal ecosystems, and man-made systems like urban communities and global corporations. He identifies three defining features shared by each. First, the networks serve the entire system and fill the entire space that is available. Second the terminal units in the networks share common design features and are essentially the same, whether they are the capillaries that provide nutrients and oxygen to peripheral tissues or the electrical outlets that enable access to the grid for home appliances.First, the networks serve the entire system and fill the entire space that is available. Second the terminal units in the networks share common design features and are essentially the same, whether they are the capillaries that provide nutrients and oxygen to peripheral tissues or the electrical outlets that enable access to the grid for home appliances. Finally, there is a natural selection process at work that is constantly optimizing the network function. West emphasizes that these defining features of complex systems are present in biological systems like the human circulatory system, coastal ecosystems, and man-made systems like urban communities and global corporations.

These common features enable West to identify fairly simple mathematical formulas that predict the relationship between changes in size and efficiency of complex systems. In general, in biological systems size and energy consumption are scaled sublinearly, i.e., metabolic rate does not increase to the same extent as size. The limits to growth occur because of the increased demands for maintenance of the system. What makes Scale an innovative work is West’s effort to apply the scaling laws derived from observations in nature to man-made complex systems such as cities and companies. He identifies two distinct components in these human systems, the materials that constitute the infrastructure and the creative work that is produced. West then demonstrates that while the physical demands of these complex human systems, such as roads, electricity, and water supply, which mirror the metabolic requirements of biological systems, increase sublinearly, the productive output like wages, theaters, and patent activity, which have no parallel in non-human biological systems, increase supralinearly. Moreover, this inventive works requires a proportionately increasing input of resources as size increases. West tries to draw lessons about the rational limits to growth by extrapolating from the scaling laws that underlie biological complex systems to the two components of the artificial systems created by mankind. West cautions against blind reliance on “big data” alone to solve the pressing social problems confronting mankind. Instead, he advocates for delineation of underlying mathematical principles to guide the analysis of the growth of cities and companies and rational future planning.

View full annotation