Summary:

Shannon Moffett, a medical student at Stanford University School of Medicine, became fascinated with the brain during her anatomy and neurobiology courses. She set off across the country to interview people--scientists, doctors, patients, ethicists, and religious leaders--who devote their careers trying to understand the brain and cognition. With infectious enthusiasm and energy, Moffett brings the reader to meet these dedicated people, their work, their theories and their lives.

The book contains eight chapters and hence eight mini-biographies: 1) neurosurgeon Roberta Glick, 2) cognitive neuroscientist and brain imagist John Gabrieli, 3) Francis Crick (of DNA double helix fame) and Christof Koch--scientists studying consciousness, 4) sleep researcher Robert Stickgold, 5) Judy Castelli who has dissociative identity disorder (multiple personality disorder), 6) philosopher Daniel Dennett, 7) neuroethicist Judy Illes, and 8) Zen monk Norman Fischer.

Separating the chapters are "interludes" that map neural and brain development from conception to death. The book has a reference list for each chapter and a complete index, as well as a web resource (www.shannonmoffett.com) to which the reader is directed for graphics.

The writing is compelling, direct, fresh and insightful. For example, in "Touching the Brain," we follow the exhausting lifestyle of an academic neurosurgeon who works at Cook County Hospital in Chicago as she performs surgery, teaches, attends services at a temple, drives her car, takes care of her family including two young children, rounds on patients, hosts a potluck dinner, and simultaneously discusses her reading, travel and spirituality.

Moffett aptly describes Glick with her "waist-length red hair, ... beaten-metal earrings dangling almost to her shoulders and a saffron batik dress" as someone you'd "expect to find reading storybooks to kindergartners in a public library" (8). In fact, it is Moffett's eye for accessible detail that makes not only the people, but also neuroscience come alive. Artfully woven into the text are lessons on the history of brain research and current understanding (and questions) about the brain, its meaning and function.

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Summary:

Richard Koslowski, a 32-year-old computer systems supervisor and musician, breaks a tooth when he bites an olive pit. Although the remnant of the damaged tooth is removed during his initial visit to the dentist, Koslowski embarks on a peculiar quest. He longs to find a perfect-fitting dental bridge, to eliminate a mysterious oral pain, and to measure up to the suffering his parents have endured as survivors of concentration camps.

He eventually elicits opinions or treatment from ten different dentists and specialists. Koslowski realizes that he has sustained more than just a cracked tooth. His entire life is now fractured. Koslowski becomes obsessed with his teeth. His girlfriend, Lisa, is a law student who is passionate about women's rights. She travels to Bosnia to interview and assist rape victims. When Lisa returns, she breaks up with Koslowski. His suffering seems so small and his life so insignificant that she can no longer tolerate him.

Koslowski's father is dying of a brain tumor but remains stoic until the end. Koslowski, on the other hand, has a poor pain tolerance. After undergoing multiple dental procedures--tooth extraction, root canals, a series of gum cleanings every week, and finally dental implants--Koslowski ultimately resigns himself to living with the discomfort in his mouth. His "reward" is marriage to a disabled woman, three children, and an ordinary life filled with minor ailments and nuisances.

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Summary:

After being struck by a speeding car while riding his bicycle, Paul Rayment suffers extensive damage to his right leg. An above-knee amputation is performed by a young surgeon, Dr. Hansen. Paul is a 60-year-old former photographer who lives in Australia. Divorced and childless, he has no one to assist him with the activities of daily living after he is discharged from the hospital. He refuses a prosthesis. Paul's accident and loss of a limb have triggered a reexamination of his life. He now regrets never having fathered a child. Paul's life is further complicated by three unusual women.

He hires a Croatian lady, Marijana Jokic, as his day nurse and aid. He is attracted to and dependent on the much younger Marijana. Although she is married and has three children, he lusts for her. He offers to act as a godfather for Marijana's children and provide funds for their education. Drago, Marijana's oldest child, lives with Paul for a while. Drago and his father build a customized cycle to convey Paul, but the crippled man doubts he will ever ride it.

Paul has a single sexual encounter with a woman blinded by a tumor. Her name is Marianna. He is blindfolded during the affair and pays her afterwards. A novelist with a weak heart, Elizabeth Costello, intrudes on Paul. The elderly woman is mysterious. She pesters him, occupies his apartment without an invitation, and peppers him with questions. In time, all three females fade from his world, leaving Paul still struggling to adapt to loss and a new life.

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Summary:

Joan Didion has written a very personal, powerful, and clear-eyed account of her husband's sudden and unexpected death as it occurred during the time their unconscious, hospitalized daughter was suffering from septic shock and pneumonia.

Quintana, the couple's 24-year-old adopted child, has been the object of their mutual care and worry. That John Gregory Dunne, husband and father, writer and sometime collaborator, should collapse from a massive, fatal coronary on the night before New Year's Eve at the small dinner table in their New York City apartment just after their visit with Quintana can be regarded as an unspeakable event, beyond ordinary understanding and expression. "Life changes fast . . . in the instant. You sit down to dinner and life as you know it ends" (3).

As overwhelming as these two separate catastrophes are, the account provided by Didion evokes extraordinary descriptions of the emotional and physical disorientations experienced by this very lucid, but simultaneously stunned and confused wife, mother, writer dealing with the shock of change. Her writing conveys universal grief and loss; she spins a sticky filament around the reader who cannot separate him or herself from the yearlong story of difficult, ongoing adjustment.

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Summary:

When their young son dies from kidney failure, Stewart and Sharon Mackaney funnel their grief into a business--transporting donated organs for transplant patients. Sharon has put on weight and not cut her long hair since the death of her child, Matthew. The fortyish woman likes to read about vertebrate organs in a worn copy of Gray's Anatomy. She totes a red cooler on her trips crisscrossing the country. Inside of it is a precious organ--a kidney, liver, or pancreas.

Sharon spends lots of time in airplanes, hotels, and bars. Although they continue to share a house, she and her husband have been estranged since Matthew's death three years earlier. Stew suffers from irritable bowel syndrome and chronic flatulence that began at his son's funeral and has not improved a bit despite psychiatric treatment.

Stew and Sharon receive an award for their work as organ transporters. During a speech at the fundraising event, Sharon criticizes the audience for hoarding their kidneys. On returning home, she spends time in Matthew's bedroom and later has a variation of the recurrent nightmare that has plagued her since her son's death. Sharon dreams that her hair is gone, and she rises, unencumbered, until reaching the ozone layer where she is incinerated.

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In 1918, the lives of ordinary Americans are disrupted by two cataclysmic events--an epidemic of influenza and World War I. Lydia Kilkenny is a young woman who works in a Boston department store. She falls in love with Henry Wickett, a sensitive and sickly man who is enrolled in medical school but has little enthusiasm for becoming a doctor. After marriage, Henry drops out of medical school. He tries to enlist in the army but is rejected.

Henry turns his attention to "Wickett’s Remedy"--a tonic accompanied by a handwritten letter emphasizing hope and encouraging recovery. Lydia designs the product’s label and concocts the placebo (based on ingredients revealed to her in a dream). The Remedy is an unsuccessful business venture for the couple.

A businessman named Quentin Driscoll likes the taste, however, and sells the Remedy as a beverage (QD soda). Although Driscoll promises to share future profits from the sale of the soda pop with Henry and Lydia, he fails to honor the agreement. QD soda eventually becomes quite popular, but Lydia never reaps any of the financial gain.

Influenza claims the lives of the two most important men in Lydia’s life--her brother, Michael, and her husband, Henry. She feels helpless and decides to volunteer at the local hospital where she cares for patients with the flu. Lydia realizes that she wants to become a nurse and signs up for a Public Health research project investigating how influenza is transmitted. Unfortunately, none of the test subjects (Navy deserters) contract the flu during the study, but a promising young doctor dies of influenza and pneumonia. Lydia later marries one of the men she meets during the research project.

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Summary:

A screening chest X-ray reveals the presence of a cardiac myxoma in a 72-year-old dictator. His personal physician (fearing for his own life) timidly informs Mr. President about the tumor and the likelihood that it will claim the dictator's life in a matter of months. The physician lacks the training and ability to remove the tumor but recommends Dr. Gala Sampras as the surgeon most qualified to perform the procedure.

Slight problem: Sampras was one of 14 surgeons who "disappeared" in 1992 after criticizing the dictator and his regime. She was imprisoned and abused in a labor camp. Her husband and three children were also removed from society. A bargain is struck. Sampras will do the operation. After the surgery is done, she will be reunited with her family.

The dictator shows Sampras pictures of her family. Although the photos of her children appear to be recent, the picture of her husband seems to have been taken years ago. On the day of surgery, the dictator directs the doctor's attention to the courtyard where soldiers surround her daughter. Sampras realizes the dictator might not survive the operation given the complexity of the procedure and the patient's age. Before succumbing to his anesthesia-induced sleep, the dictator is told by Sampras not to worry, but her every move is closely monitored by his soldiers. The night is likely to be long and hard for the doctor and the dictator.

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Summary:

This is the last published entry in the journal kept by author Harold Brodkey, before he died of AIDS on January 26, 1996. Brodkey, ever the flamboyant writer, began a record of his diagnosis with AIDS and "my passage into nonexistence" in the pages of The New Yorker (see also earlier journal entry, Dying: An Update, annotated in this database).

In this last entry he focuses intensely on the end of consciousness that looms ahead. In spare poetic phrases he describes what he is attempting to grasp-- " . . . this wild darkness, which is not only unknown but which one cannot enter as oneself." He reflects also on memory, medication, creature comforts, family history, the legacy he leaves, and describes with amazement that he feels happy.

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Summary:

This two-page story is a tour de force. A jaded book critic, known to us only as Anders, is standing on a long line at the bank. He engages in sarcastic, belittling repartee with the women on line ahead of him. Suddenly two ski-masked bank robbers--one with a sawed-off shotgun--appear and threaten everyone.

Anders can't keep his acid tongue quiet. He seems incapable of recognizing the real danger and instead keeps up a commentary, like a cynical uninvolved reviewer. He explodes with laughter--and is shot in the head. "Once in the brain . . . the bullet came under the mediation of brain time . . . ." "It is worth noting what Anders did not remember, given what he did remember."

The remainder of the story is a list of incidents that the victim does NOT remember, during the seconds while he is dying, followed by what he does recall. The bullet, "in the end . . . will do its work and leave the troubled skull behind, dragging its comet's tail of memory and hope and talent and love . . . . "

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Summary:

A neurosurgeon looks forward to having a day off from work, but a promising Saturday brings only trouble. Henry Perowne is 48 years old and practices in London. Lately, he's concerned about the impending invasion of Iraq. Perowne's views on the situation have changed considerably after conversations with a patient who was tortured and imprisoned in Iraq for no apparent reason. A protest march against the looming war is held on Saturday.

On his way to play a game of squash that morning, Perowne is involved in a car accident on an otherwise deserted street. No one is injured and the two vehicles sustain only minor damage. The owner of the other car is a man in his twenties named Baxter. He is accompanied by two buddies. Perowne refuses Baxter's demand for cash to repair the car so Baxter punches the doctor. Perowne is moments away from a pummeling.

He notices that Baxter has a tremor and an inability to perform saccades. Perowne deduces that Baxter has Huntington's disease. The doctor capitalizes on the fortuitous diagnosis. He speculates that Baxter has kept the neurodegenerative disorder a secret from his sidekicks. When Perowne initiates a discussion about the illness, Baxter orders the cronies away so that he can speak privately to the doctor. The two men desert Baxter, and Perowne escapes in his car, hopeful he can still make the squash game.

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