Summary:
Editing Humanity explores the history, biology,
sociology, and ethical import of CRISPR (“clustered regularly interspaced
short palindromic repeats”), the major new DNA technology indicated in the
book’s subtitle, “The CRISPR Revolution and the New Era of
Genome Editing.” Using CRISPR, researchers can
manipulate the DNA of animals, plants and microorganisms with extremely high
precision. In particular, scientists now have the potential to customize
the human genome.
What is
CRISPR? To quote Davies, “CRISPR is a small subsection of the bacterial genome
that stores snippets of captured viral code for future reference, each viral
fragment (or spacer) neatly separated by an identical repetitive DNA sequence.”
(p. 23) When the cell is reattacked by a virus, an RNA copy of that virus’
stored “signature” forms a DNA-splitting complex that destroys the incoming
virus. In 2012, Jennifer Doudna, of the University of California, Berkeley, and Emmanuelle
Charpentier, of the Max Planck Institute, Berlin, demonstrated that CRISPR
could be engineered to edit any gene. One could, for example, replace a
disease-causing mutation in any DNA segment with the healthy variant, thus
preventing genetic disease.
The author,
Kevin Davies is
a geneticist and science writer whose previous books include Cracking the
Genome and DNA: The Story of the Genetic Revolution. In Editing Humanity, he discusses an
array of actual and potential applications of CRISPR technology, including
human disease prevention by altering susceptibility of animal vectors,
improving farm productivity, and even resurrecting extinct species. However,
the most powerful and controversial topic is genetic manipulation of the human
embryo. Davies devotes several chapters to the cautionary tale of the young Chinese scientist He Jiankui who
engineered the world’s first gene-edited babies, and the scandal and disgrace
that followed. (He was convicted in China of “illegal medical practice” and
sentenced to prison.)
View full annotation