Elizabeth Mann, the daughter of a world famous fertility specialist whom she despises, hasn’t quite made it into medical school. She runs away to London, where she can revel in an orgy of self-destructive behavior, while working as a freelance writer for a travel guidebook. She soon develops two obsessions. In an obscure medical museum she encounters the skeleton of Jonathan Wild, a famous 18th century criminal who met his death by hanging. During the same museum visit, she runs across Gideon Streetcar, a young fertility specialist who once worked with her father. Though Gideon is "happily" married, he and Elizabeth soon begin a torrid affair.

Elizabeth’s obsession with Jonathan Wild grows when, through Gideon, she obtains a copy of the criminal’s second wife’s memoir. Through it, she learns that his first wife, who died in childbirth, was named Elizabeth Mann. She develops a scheme to obtain DNA from Wild’s skeleton and use it in association with an experimental cloning procedure to become pregnant with the 18th century criminal’s child (clone).

When the 25 year old Elizabeth reveals that her father tied her tubes when she was 16, after having aborted her fetus--a "slut," he called her--Gideon agrees to attempt in vitro fertilization with her eggs and his sperm. He transfers two blastocysts, plus one of the supposedly cloned Jonathan Wild cells. She becomes pregnant. Soon thereafter she returns to the USA when her father has a massive heart attack and she, apparently, has an opportunity to go to medical school.