In 1780, Thomas Silkstone, a young American
surgeon and anatomist, is invited by Lydia to establish the cause of death of her
brother, Lord Crick, a dissolute who held the Oxfordshire estate that she will
inherit. Her goal is to absolve her husband of the suspicion of murder;
however, as the investigation proceeds, it increasingly seems that her husband is
guilty after all.
The earnest young doctor methodically
examines each new lead—performing experiments on tissues and with various
poisons in his effort to determine the cause of death – and in so doing solve a
murder. Before long, another person is dead and Thomas is in love with Lydia, a
scarcely concealed complication that calls his testimony into question.