Tom Hogue is a nonpracticing Catholic who develops a mysterious dermatologic disorder. Five areas of chapped and painful skin located on his hands, feet, and below his ribs begin to bleed simultaneously. The reluctant stigmatic soon experiences weight loss and insomnia and has premonitions. He attempts self-treatment before consulting in order his local pharmacist, primary care physician, a dermatologist, and eventually a psychiatrist.
He is diagnosed as having "psychogenic purpura" and his condition seems to improve with psychiatric treatment. Initially Hogue questions the validity of his stigmata and is uneasy with his religious celebrity. When his affliction spontaneously resolves, he has difficulty adjusting to his new life. A chance encounter with a woman whose life had been profoundly affected by Hogue when he still retained the stigmata leads him to consider self-mutilation as he fondles a steak knife beneath the table during their conversation.
While still dating, Sami learns that she is pregnant by Steven. The couple gets married and begins the transformation into prospective parents. Steven's study is turned into a nursery. Sami starts bleeding during the pregnancy and she is placed on bedrest. Unfortunately, Sami has a miscarriage.
When Steven finally decides to clean out the nursery, he finds a sad child occupying the room. Sometimes the baby disappears. After Steven informs his wife about the nursery's occupant, Sami is initially upset but soon she too sees the baby. She dubs the child "Stevie" and accepts the boy as her own, even nursing the baby. Slowly Steven comes to embrace the child as his son, unsure what he had resisted for such a long time.