Tom Hogue is a nonpracticing Catholic who develops a mysterious dermatologic disorder. Five areas of chapped and painful skin located on his hands, feet, and below his ribs begin to bleed simultaneously. The reluctant stigmatic soon experiences weight loss and insomnia and has premonitions. He attempts self-treatment before consulting in order his local pharmacist, primary care physician, a dermatologist, and eventually a psychiatrist.

He is diagnosed as having "psychogenic purpura" and his condition seems to improve with psychiatric treatment. Initially Hogue questions the validity of his stigmata and is uneasy with his religious celebrity. When his affliction spontaneously resolves, he has difficulty adjusting to his new life. A chance encounter with a woman whose life had been profoundly affected by Hogue when he still retained the stigmata leads him to consider self-mutilation as he fondles a steak knife beneath the table during their conversation.