Angelo Pardo, an idealistic young Piedmontese freedom fighter and cavalry officer, is living in exile in Provence and making his way to join his best friend in Manosque, when a cholera epidemic transforms the countryside, towns, and social structure of the region. By turns, he aids an altruistic doctor in futile attempts to save the dying, lives as a fugitive on the roofs of Manosque, helps a nun to dispose of the dead, and accompanies a beautiful young woman, Pauline, to her home near Gap. His adventures illustrate the transformations produced by an epidemic and the means taken for survival.