Dr Bernard Rieux (William Hurt) says good-bye to his ailing wife at the Oran airport in South America. Their only child is dead. She has gone to the distant capital for tests and he plans to join her in a few days. But a mysterious epidemic of rats and what turns out to be bubonic plague breaks out. The city is sealed by draconian authorities who separate family members and drag people from their homes. Rieux decides to stay; months pass and his wife will die before he can see her again.
He befriends two stranded French journalists, Martine (Sandrine Bonnaire) and Tanto (Jean-Marc Harr), who volunteer as aides. They visit Joseph Grand (Robert Duvall) who keeps the cemetery statistics and writes an interminable novel. Tanto and Grand contract the disease but manage to survive under Rieux's care.
Constantly palpating her body in fear, Martine is desperate to flee, even as she strives to evoke passion from the emotionally numb Rieux. She is robbed and incarcerated by Cottard (Raul Julia) an unscrupulous profiteer. As the epidemic wanes, the journalists, the doctor, and Grand are reunited, but in that same instant Cottard shoots Tanto dead. Rieux and Martine are left sobbing in each others arms.
