Will Raven is a medical student beginning his apprenticeship with Dr James Young Simpson. He has been involved with a prostitute Evie whom he finds murdered. Simpson’s housemaid, Sarah Fisher, takes a dislike to him, not least because of his educational and social privileges. She is barred from such opportunities because of her gender and class, despite her greater intelligence. Sarah studies medicine on her own. Coming from poverty, Raven is nevertheless, pompous, chauvinistic, quick to fight, and desperate to earn money and status. Like Evie, other young girls are being brutally murdered in the Old Town of Edinburgh, and Raven and Sarah are separately motivated to find the killer. Their master, Simpson, is conducting experiments with anesthesia and suspicions are cast upon him. Although Raven and Sarah are part of his household, they find his behavior mysterious. Eventually they collaborate to solve both mysteries.