Visual Arts
- The Old Guitarist (The Blind Guitarist)
- An Old Man and His Grandson
- One Breath Apart: Facing Dissection
Literature
- The Oath
- Oaxaca Journal
- Obsessive Genius. The Inner World of Marie Curie
- Odd Leaves from the Life of a Louisiana Swamp Doctor
- Ode on a Grecian Urn
- Ode on a Lycian Tomb
- Ode on Melancholy
- Odour of Chrysanthemums
- Oedipus the King
- Of All the Dead That Have Come to Me, This Once
- Of Dragons and Garden Peas: A Cancer Patient Talks to Doctors
- Of Experience
- Of Human Bondage
- Of Love and Other Demons
- Of Medicine and Poetry
- Of Mice and Men
- Of Mist, and Grass, and Sand
- Of My Death
- The Office
- The Old Curiosity Shop
- Old Doc Rivers
- Old Folk's Home, Jerusalem
- Old Ironpuss
- Old Ladies' Home
- An Old Man
- Old Man Playing with Children
- Old Mrs. Harris
- Old People
- Old People on the Nursing Home Porch
- Old Souls: The Scientific Evidence for Past Lives
- Oleanna
- Olive
- The Omnivore's Dilemma: A Natural History of Four Meals
- On Being a Cripple
- On Being a Doctor
- On Being Ill
- On Bittersweet Place
- On Chesil Beach
- On Death
- On Easter Eve
- On Living
- On Looking Further into the Bodies of Men
- On My First Sonne
- On Official Business
- On Studying Anatomy
- On the Couch
- On the Death of a Parent
- On the Harmful Effects of Tobacco
- On the Move: A Life
- On Wings of Spirit: Anthology of The American Physicians' Poetry Association
- On with the Story
- Oncological Cocktails
- One Breath
- One Crimson Thread
- One Friday in April
- One Hundred Days: My Unexpected Journey from Doctor to Patient
- One Last Time
- One More Time
- One of Everything
- One of These Days
- One Ordinary Evening
- One Thousand Years: Poems about the Holocaust
- One True Thing
- One Word
- One Word
- Only Goodness
- Only Morning in Her Shoes: Poems About Old Women
- Only Yesterday
- Ooh Baby Baby
- Open Heart
- Open Heart
- Open Workings
- Open Wound: The Tragic Obsession of Dr. William Beaumont
- Opera: Desire, Disease, Death
- Operating Instructions: A Journal of My Son's First Year
- The Operation
- Operation Wandering Soul
- The Opposite of Fate: A Book of Musings
- Or Perish in the Attempt: Wilderness Medicine in the Lewis and Clark Expedition
- The Orange Wire Problem and Other Tales from the Doctor's Office
- Orchids
- Ordeal by Hunger
- Ordinary Grace
- Ordinary Grace
- The Origin of Music
- Original Sin
- Oryx and Crake: A Novel
- Oscar and the Lady in Pink
- Othello
- The Other Man Was Me: A Voyage to the New World
- Other Women's Children
- Otherwise
- Otherwise: New and Selected Poems
- Our Cancer Year
- Our Human Hearts: A Medical and Cultural Journey
- Our Lady of the Lost and Found: A Novel
- Our Menstruation
- Our Missing Hearts
- Our Mutual Friend
- Our Parents
- Out of Habit, I Start Apologizing
- Out of Ireland
- Out of Mind
- Out of My Bone: The Letters of Joy Davidman
- Out of My Life and Thought
- Out of Sight
- Out of the Bag
- Out of the Woods
- Out the Window
- Outlook
- Outpatient
- Outside Passage
- The Outsider: A Journey into My Father's Struggle with Madness
- Oysters