Keats urges his reader not to respond to melancholy by committing suicide. He says to avoid poisons like Wolf's-bane, nightshade, and yew berries. Instead, when most depressed, "glut thy sorrow" on the beauty of a rose or the rainbow of salt and sea. Likewise, if your mistress is angry with you, look into her eyes and feast on their ephemeral beauty.

Contrast is the key to pleasure. Melancholy is not the moment for death, but an opportunity for a fine experience. It is the fine balance between pain and pleasure that is ideal. The final stanza rephrases this idea. Beauty is always ephemeral; joy is always about to leave, but these are man's highest moments.