Rx/Museum is a wonderful example of collaboration and integration of the arts, humanities, and medicine to teach or renew a sense of empathy, connection, and new perspective. The essays strike a successful balance of being accessible to those who have no prior knowledge of art history, while also engaging those who are well-versed in medical humanities and are seeking fresh inspiration. The prompts at the end of each essay challenge readers to consider diverse topics related to medicine, ranging from social injustice, to friendship, to the patient-clinician relationship. Many of the reflections also specifically address the challenges brought on by COVID-19, and will continue to be relevant as healthcare workers face the aftermath of the pandemic. This is especially true of clinicians struggling with burnout, who might find meaning and sustainability in their future work through the lens of art.