In the 1527 sack of Rome, undiscplined troops of the Holy Roman Emperor rape, pillage, and destroy. The beautiful couresan Fiammetta Bianchini opens her house to the marauders, inviting them inside for food and comfort. The act gives her household a moment’s reprieve. Her golden tresses savagely shorn, she swallows her jewels and escapes north to her native Venice in the company of her servant and companion, the dwarf, Bucino Teodoldi.

Arriving with almost nothing, they set about establishing a reputation and securing backers. The small company is helped by Fiammetta’s friend and admirer the satirist and poet, Pietro Aretino. Her portrait is painted by his friend, Titian.

Clever and loyal to a fault, Bucino frets over finances and willingly engages in subterfuges that mesmerize their audiences. Fiammetta accepts the attentions of tedious but wealthy admirers in exchange for a house and status. She comes to rely on a blind woman healer, called La Draga who supplies medicine and cosmetics. Bucino is suspicious and jealous, but he tolerates the competition grudingly. He too has many ailments, including headaches and arthritis, because of his deformity.

Suspense swirls around a banned book, a Jewish shopkeeper, and La Draga’s mysterious origins in the glass-making town of Murano.