Living in Bombay, India, Sera (Souad Faress) and Sam (Khodas Wadia), a beautiful Parsee couple who adore dancing, have a son (Firdaus Kanga) who will never grow and never walk because he has osteogenesis imperfecta (brittle bone disease). They name him Brit, for his bones. As narrator, Brit says that Sera suffers from the "Parsee disease of anglophilia." But she accepts Brit’s disability.

His father, however, does not; and he continuously appeals to magic, folklore, and religious healers, hoping to find a cure. He professes love for his son, but is never able to forge a confident bond. Brit does not fail to criticize. Sam’s quest leads to a woman scholar who nurtures the boy’s intelligence and encourages him to write a diary and short stories.

Brit’s older sister is his staunchest ally and best friend, but she eventually must leave for a marriage in America. Sam escorts his daughter to America, where he commits suicide on Fifth Avenue. Brit and his mother come to rely heavily on a widow friend and her deaf daughter, "promised" to Brit in childhood.

But the girl is soon spirited away on a wave of romanticism into a life of prostitution. They take a boarder, Cyrus, a gifted and handsome law student who offers Brit a new world of night life, action, dancing, and physical affection; his love leads Brit to like and accept his own body. When his mother dies, Brit becomes a writer and finds a new life and a new lover.