A family epic set in rural Mississippi and spanning several generations. Often described as a road novel by reviewers, the story centers on Jojo, a 13-year-old boy struggling to protect his younger sister Kayla from the disarray of his parents' influence: one Black, one White; one in prison; both addicted to meth. These forces contend with Jojo's stoic yet caring grandfather, his mystical-spiritual grandmother, his bigoted grandparents on the other side, and the strange passenger they collect while on the road.