Harlan Jane Eagleton, a faith healer, tells the story of her evolution from being a rock star's manager and beautician into healing. She travels from tank town to tank town ("on account of them water tanks") performing faith healings. The novel begins at the end of the story and loops forward to where her story begins, Harlan Jane's first faith healing.
In the process, readers are given accounts of her life as manager of the rock star, her love affair with a paranoid German lover, and her former husband, a medical anthropologist who travels and studies in Africa. We hear about Harlan Jane also from Nicholas, her assistant, who sometimes narrates what happens at the healings.