This story, set in a hospital in a Japan demoralized by Allied air-raids, concerns an intern, Dr. Suguro, who is coopted by an ambitious senior surgeon to participate in medical experiments involving vivisection of captured American airmen. The experiments are to determine how much lung tissue can be removed before the patient dies, how much saline solution, and how much air can be injected into the blood before death occurs. Ostensibly this knowledge will improve treatment of tuberculosis which is ravaging the country. The real motivation arises from the brutality of the military, from competition among hospital department heads, and from an atmosphere of nihilism in the face of almost certain defeat by the Allies.

Dr. Suguro's acquiescence humiliates him. Paralyzed by moral conflict into non-action in the operating room, he succumbs to deeper shame and humiliation. The novel begins many years after the event, when a narrator comes as a patient to Dr. Suguro's dilapidated clinic.