Schiebinger’s historical analysis looks at the role of women and female nature in modern science in four places. These are: institutional organizations (when and how did medical schools and fraternities allow or disallow female participation?), individual biographies (who were trendsetters in the history of science?), scientific determinations of female nature (how did scientists decide what makes woman woman?), and cultural meanings of gender.

Chapter Seven is an especially disruptive chapter, analyzing drawings of female skeletons at the turn into the nineteenth century. Earlier, female skeletons had been drawn in the same way as male skeletons. At this point, however, they became thin-boned and wide-hipped. Sexual difference became far more central.