One of Hemingway's war and love stories, this novel takes place in Italy during World War I and is tied closely to the author's own experience as an American Ambulance Driver for the Italian Army. The story opens during a lull in the action and the reader meets a group of men who work with the wounded during battle. In the course of waiting for action, the protagonist, Henry, meets and courts an English nurse stationed in Italy.

The core of the tale is the evolution of the love of these two in the face of increasing military involvement, including an engagement in which Henry is wounded and after his return to the front, an Italian retreat from which he barely escapes with his life. Ultimately, he and Catherine, his English love, defect and enter Switzerland to await the birth of their child. Baby and mother both die and Henry is left alone, his future left by the author unplotted.