The Hours begins with a reconstruction of Virginia Woolf's 1941 suicide by drowning. What follows is an exploration of despair and tenacity, of the reasons that some people choose not to continue living, and of the things that enable others to go on. Patterned as a kind of theme and variations on Woolf's Mrs. Dalloway, this novel has three strands, each tracing a day in the life of a woman: Virginia Woolf herself, in 1925, as she begins to write Mrs. Dalloway; a middle-aged 1990s New Yorker named Clarissa Vaughan, but nicknamed "Mrs. Dalloway" by Richard, her ex-lover, an acclaimed writer who is dying of AIDS; and Laura Brown, a young mother in Los Angeles in 1949, pregnant, depressed, and reading Woolf's Mrs. Dalloway.

Laura's small son, Ritchie, we gradually realize, has grown up to become the Richard in Clarissa Vaughan's story and, as the hours pass in the day-long story of each woman, patterns intertwine. Clarissa (living as a lesbian, so following a path that Woolf's Mrs. Dalloway was offered but chose not to take) is planning a party for Richard. Laura is preparing a birthday dinner for her husband but after a visit from the woman next door, whom she kisses in a moment of profound but disruptive empathy, she checks into a hotel room to read, and to consider suicide. Woolf, recognizing the deep connection between her mental illness and her writing, tries to flee from the faintly suffocating safety of her home and husband.

Each woman survives, and all three days end with a sense of qualified and temporary happiness, drawn together, I think, by the fictional Virginia Woolf's decision about her novel: throughout the day she has thought about her main character, and has intended the book to end with her suicide. Late in the evening, having returned home, Woolf decides to let Mrs. Dalloway live: "sane Clarissa--exultant, ordinary Clarissa--will go on, . . . loving her life of ordinary pleasures, and someone else, a deranged poet, a visionary, will be the one to die."