Showing 131 - 140 of 202 annotations tagged with the keyword "Science"
Rosenberg, a surgeon and bench research scientist, has an epiphany fairly early in his clinical career: a patient with widespread cancer determined to be terminal, returns to the clinic sometime later, apparently disease-free without medical treatment. The scientist wonders if this patient's body could have tapped into some immunological or genetic healing pool. After having formulated the question, the author takes the reader through the trials and tribulations of framing, trying, failing, retrying and failing again to determine a way to test and prove how this phenomenon could have happened.
Over the many years of experimental work in the laboratory and on the wards of the National Cancer Institute, Dr. Rosenberg presents in a fashion largely accessible to the lay public a glimpse into this process. The work covers nearly three decades of the author's struggle to better understand and to develop new treatments for malignancies.
Henry Moss is a medical geneticist specializing in Hickman syndrome, a fictitious disease resembling progeria. Children with Hickman syndrome experience premature aging and invariably die before the age of twenty. The physician meets Thomas Benhamouda, a teenager who genetically has Hickman syndrome but astonishingly has no physical manifestations of the disease. Dr. Moss identifies a protein that "corrects" Hickman syndrome in the blood of Thomas and proceeds to synthesize it.
Dr. Moss violates medical ethics by administering the experimental enzyme to his favorite Hickman patient, William Durbin, a dying 14-year-old boy. It is a last-ditch effort to save William's life even though the substance has not been tested for safety or efficacy in human beings. Dr. Moss also injects himself with the enzyme. He realizes the tremendous potential the drug has not only in curing Hickman syndrome but also in extending longevity in normal individuals. He is well aware of the great financial rewards he might reap from his discovery.
After a series of injections, William's deteriorating health stabilizes and even improves but he dies in his home. Dr. Moss has failed to save the doomed boy but in the process of breaking the rules and risking his career has learned how to understand and appreciate his own life as well as reconnect with his family.
This chapbook by Kentucky poet Leatha Kendrick features a sequence of poems dealing with her experience of breast cancer and mastectomy. The "science" in the title moves from a little girl’s fascination with nature, and her insight that "all she learned was nothing / is only what you thought you saw" (p. 2); through her mature view of "these spiky shadows" on ultrasound (p. 10); to chemotherapy, where she feels "like the muck this stuff is supposed to make of the fast- / dividing cells" (p.18).
But the science of cancer fails to amputate the poet’s narrative. Early on, "My first love called them Skeeter and Bite. / Equal then, if small. Skeeter got / most of his attention." (p. 14) Later, during her treatment, "Excuse me while I grow bald and fat." (p. 21) Eventually she learns, "The map back is a flat / red road, underpinned with bone, / she must learn to dance upon." (p. 28).
Emiko a child survivor of Hiroshima, is now a documentary filmmaker. She has horrific memories of August 1945 when she lost her parents and little brother, and of the years of painful operations and homesickness in America where she was sent to restore her mutilated face. She is hoping to interview Anton Böll, a scientist who had fled Germany to work on the Manhattan project.
Böll contends that he had been unaware of human rights abuses; he left Europe because the Nazi regime had cramped his scientific style. As a consequence, his mother was imprisoned and killed. During the war, he met his Austrian-born Jewish wife, Sophie, at a displaced persons camp in Canada. Sophie had lost her whole family, but she does not speak of them and he does not ask.
Briefly they knew happiness, but soon Böll left for work on the bomb and on to Hiroshima in its aftermath. Their marriage would never be the same. For the rest of his life, Böll justified his involvement as a "dream" turned "nightmare" emerging from the imperative demands of a virtuous science. When Emiko approaches him, he hesitates. He does not want to risk blame. But his dying wife knows that absolution for unacknowledged guilt is what he craves.
A man and woman, probably late middle-aged and married, check into a tropical holiday resort for their last annual vacation. One of them is dying. The man begins telling stories to the woman, as he has promised to, in the unspoken hope of postponing the ending that will separate them. The book consists of the twelve stories he tells, interspersed with her responses to the stories. Each story is in some way about the same two things: about being half of a couple--about love, partnership, and the prospect of loss--and about narrative--about communication, the construction of meaning, and about the way all stories (and lives), sooner or later, must end.
Like their teller, though, these stories do their best not to reach closure. An example is the second story, "Ad Infinitum," in which a woman receives some bad news by telephone--we deduce it concerns her husband's cancer diagnosis--and goes out to where he is working in the garden in order to tell him the news. She has to cross the space of the garden before giving him the information that will change everything for the worse, beginning the end of his life and their marriage.
It occurs to her that the space she must cross can be infinitely extended if, as Zeno's paradox has it, she can keep halving the distance that remains before she reaches her husband (and thus the end of their story). This would infinitely suspend time in their story. And yet, as she walks, she also knows she WILL reach him . . . until the narrator intervenes by breaking into her thoughts and beginning another story, effectively enacting Zeno's theory of the arrow that keeps re-beginning its flight towards the target. Just as stories stave off death in the frame narrative, they seem able to keep this man happily and innocently gardening, in suspended story-time at least, forever.
In the last story, the narrator returns to all the others, pulling together their interconnected patterns and allowing each a kind of closure that, while it reiterates the storyteller's resistance to endings, his act of "beguiling" himself, his wife, and perhaps death itself, "with narrative possibilities still unforeclosed" (224), also reminds us that stories need to end in order to mean.
This thorough and fascinating treatment of the politics of anatomy studies in 19th-century America provides a variety of perspectives on the vexed question of how appropriately to study human anatomy while also maintaining respect for the human body and honoring the various, deeply held community beliefs, and attitudes toward treatment of the dead. Sappol seeks, as he puts it, to "complicate the cultural history of medicine in late-eighteenth- and nineteenth-century America. . . by telling it from an anatomical perspective."
That statement of his objectives hardly suggests the startling range of approaches to the topic he takes in the book's nine chapters. These cover such issues as the legacies of belief about the "personhood" of the dead human body; the status of anatomy as both a legitimate and valuable study and also as an "icon of science"; the relationship of dissection and anatomy study to medical status and professionalization; the political tensions engendered by the "traffic in dead bodies" that most often expropriated corpses from marginalized communities; and the relationship of anatomy studies to sexual commerce and sensationalist fiction.
This gripping narrative traces the history of the efforts to eradicate smallpox in the 1970s, the top-level decisions to keep a few vials of it for emergency purposes in American and Soviet freezers, and the reemergence of smallpox not only as a health threat, but as a potential bioweapon of unequaled destructive power. Preston details maverick natural cases that surfaced after worldwide eradication efforts, how it was discovered that undocumented reserves of smallpox were not only being kept, but researched and possibly "weaponized," and how hotly, in the US, teams of scientists and military intelligence personnel debated funding new smallpox research in the US with a view to developing a new vaccine as a defense.
The ethical issues in those debates are unprecedented in the scope of the possible public health threat and the variables that might make traditional vaccination ineffective against the weaponized virus. As in his previous books on biological threats, The Hot Zone and The Cobra Event (see annotation), Preston follows the work and lives of several key scientists and includes scenes from interviews with a variety of persons involved in confronting the political, ethical, and medical dilemmas posed by smallpox research and efforts to track and control it.
Max Vigne, the most junior member of a survey group mapping the Himalayas in the 1860s, writes letters to his young wife Clara in England. She has prepared in advance of his journey a series of postdated letters which he keeps in his trunk. When these have been read, Clara sends numbered letter packets which arrive sporadically, out of sequence, if at all, over the months of the expedition. Max struggles to describe and to edit his daily experiences on the mountains which are extraordinary, often terrifying, and disorienting for him.
Separated by time, distance, and experiences, they are slowly and irrevocably estranged. Max discovers that his real scientific passion is alpine botany, and he must decide how to tell Clara that he will not be returning to England after the Survey ends. The exchange of letters ingeniously maps out the complexities between Max's love for his wife and his passion for scientific knowledge, and the wide expanse between them.
When literature and cultural studies professor Michael Bérubé's son James was born in 1991, he was diagnosed with Down Syndrome. Negotiating various medical, social, and educational environments and the identities each assigns their son, Bérubé and Janet Lyon (his wife, a literature professor and former cardiac-ICU nurse), become effective advocates for Jamie and embark on a course of questions about the social systems that produce disabled identities and administer to those human differences termed significant ones. Bérubé engages these questions with a mixture of family experience (his own, and that of other families with disabilities), historical research, critical theory, and sophisticated critical analysis.
Another Dimension is an occasional feature of the journal, Emerging Infectious Diseases, published by The Centers for Disease Control and Prevention (CDC). These essays (and occasionally poems or stories) focus on human and philosophical issues related to medical practice, scientific research, and public health. The intention of this feature is to bring a new perspective to the journal’s coverage of medical science and public health. Some of the essays include a painting or other image that draws attention to the subject matter of the essay.
Managing editor, Polyxeni Potter, with the encouragement of Joseph E. McDade, founding editor of the journal, initiated and is guiding this feature (see also the annotation of Potter: Emerging Infectious Diseases cover art). Since this is a government site, its material is freely available on-line.