Summary:

Miranda's narrative opens with a fretful dream foreshadowing death as the first hint that she is becoming ill during the course of the deadly influenza epidemic of 1917-18. The tightly woven story takes the reader through a month of Miranda's life as a newspaper theatre columnist, a young single woman struggling with a relationship with a soldier about to be "shipped over," and an observer of the World War I frenzy that engulfed America.

The final pages are made up of Miranda's intermittent delirious dreams and perceptions from the depth of her illness. She slowly recovers, only to learn that her Adam has succumbed to the same illness and that the war has ended.

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In early 1847, the young Quebec city doctor, Lauchlin Grant, struggles to extract a living from his boring practice and pines over his childhood sweetheart, Susannah. She is now the wife of a prominent journalist, Arthur Adam Rowley, who has charged Lauchlin with her care, while he travels in Europe to report on the ghastly potato famine in Ireland and his predictions for its effects on immigration.

Even as Rowley's letters are read at home, waves of starving Irish land at Grosse Ile in the St. Lawrence River where thousands are ill or will sicken of ship fever (typhus), and die. Lauchlin is called to help at the quarantine station. Of the hundreds in his care, he rescues only Nora. Having lost her family, Nora decides to remain as a nurse, because she is now immune.

Lauchlin sees Susannah only once more, learning that she too cares for victims of typhus, which is also ravaging the mainland, despite the quarantine. He senses her unspoken love for him and, filled with an inner peace, returns to Grosse Ile, only to contract typhus and die. Nora takes the doctor's belongings to Susannah's home, hoping to meet the woman whose name he had mumbled in his delirium. Instead, she finds Susannah's newly returned husband dreading the loss of his now dying wife.

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A witch doctor treated a man for trachoma with a caustic root, and the man went blind. Terrified and depressed, he sat in the doorway of his home for two years while "his wives ministered" to him. One night he went off on his own and "fell into a dry well and died upside down."

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This novel was inspirational for several generations of pre-medical and medical students. It follows the hero, Martin Arrowsmith, from his days as a medical student through the vicissitudes of his medical/scientific career. There is much agonizing along the way concerning career and life decisions. While detailing Martin’s pursuit of the noble ideals of medical research for the benefit of mankind and of selfless devotion to the care of patients, Lewis throws many less noble temptations and self-deceptions in Martin’s path. The attractions of financial security, recognition, even wealth and power distract Arrowsmith from his original plan to follow in the footsteps of his first mentor, Max Gottlieb, a brilliant but abrasive bacteriologist.

In the course of the novel Lewis describes many aspects of medical training, medical practice, scientific research, scientific fraud, medical ethics, public health, and of personal/professional conflicts that are still relevant today. Professional jealousy, institutional pressures, greed, stupidity, and negligence are all satirically depicted, and Martin himself is exasperatingly self-involved. But there is also tireless dedication, and respect for the scientific method and intellectual honesty.

Martin’s wife, Leora, is the steadying, sensible, self-abnegating anchor of his life. In today’s Western culture it is difficult to imagine such a marital relationship between two professionals (she is a nurse). When Leora dies in the tropics, of the plague that Martin is there to study, he seems to lose all sense of himself and of his principles. The novel comes full circle at the end as Arrowsmith gives up his wealthy second wife and the high-powered, high-paying directorship of a research institute to go back to hands-on laboratory research.

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A powerful one person/one act play set in a police station in Manhattan. Addressing a cop "who would be at the other end of the table," Tom, a 36-year-old baker suffering from "survivor guilt," has been accused of killing his lover Johnny who had been dying from AIDS. Throughout the interrogation Tom offers insight into his and Johnny's lives prior to and during their relationship. His story also is permeated with attacks on an uncaring and ignorant society, especially when he mocks the interrogator's derogatory refrain, "You don't look like the kinna guy'd do somethin' like dat."

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It is the year 2073. A boy and his grandfather, clad in animal skins, are walking through deep woods. Having fought off a bear, they come to a fire on the beach, where several other boys sit watching their sheep. Their grandfather asks for a crab and they tease him with empty shells until he cries. Finally, they relent and ask him to tell his story about the past and the scarlet plague.

The grandfather had been a literature professor at The University of California-San Francisco. In the summer of 2013, rumors began that a new plague was killing people in New York. Those infected developed a scarlet rash, had a few convulsions, then settled into a sleep-like state in which they became numb and died, their bodies decomposing almost immediately. The entire process took at most an hour, but sometimes as little as ten minutes. Bacteriologists died even as they tried to find a vaccine. People began dying by the millions. The plague finally reached San Francisco and mayhem broke out. The wealthy tried to flee the city and the poor murdered them and looted in revenge for their long oppression.

The professor survived. He lived alone in the Grand Canyon for three years, then set out to see if anyone else was alive, finding a workingman and his woman slave. He met others and began a family which included the boys to whom he is telling his story. There is no means of communicating across the country or to other nations, since the fires set by looters consumed nearly every structure. Society has been set back to a nomad existence. The boys do not believe most of their grandfather’s story. They fight amongst one another and with him in a language that is only partly English. Finally, they rise, leaving the grandfather to straggle along behind into the wilderness.

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For those considering a comprehensive overview of plague in Medieval Europe, Hirsch’s long poem is extremely useful. Comprised of thirty-five stanzas, it provides an historical account of devastation associated with the onset of plague in Venice in 1347. An inventory of behavioral responses to catastrophic disease illustrates that responses to AIDS frequently mimic irrational behaviors associated with earlier epidemics. There are references to hysteria, scapegoating, flagellants, illness symptoms, escape, desperate cures, and religious fervor.

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A patient suffers a mysterious eye ailment that baffles the doctors. Yet suddenly, the affliction resolves, and the patient describes the simple joys of tears and what they symbolize. The mood is shattered as the patient discovers that despite all the "mercy' that tears bring, they can also be deadly, as an "AIDS-related virus" is discovered in tears.

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