Summary:

Martin Nanther is a member of the British House of Lords, having inherited his title from his great-grandfather, Henry. Physician to Queen Victoria, Henry specialized in hemophilia, the disease that Her Majesty was known to have passed to her son, Leopold, and other descendants. While the House of Lords considers a Bill to abolish hereditary peerage and Martin's much younger, second wife is obsessed with becoming pregnant, he escapes into his slow research for a biography of Henry

His patient genealogical investigations uncover deaths in infancy of several young boys in his own family, and Martin soon realizes that hemophilia (rather than the family's legendary tuberculosis) is the cause. Was that irony merely a coincidence? Or was hemophilia in his own lineage the impetus for his grandfather's research and position in life? And why was the disease hushed? Was it possible that his grandfather deliberately sought a bride with the trait in order to investigate it in his own progeny?

Martin soon finds himself wondering if this well-respected, medical man actually committed murder, or was he merely waylaid by unexpected love? Without giving too much away, suffice it to say that the answers prove so surprising and so disturbing, that Martin decides to abandon the biography of his ancestor, even as he learns that his inherited peerage has been revoked and that his next child will soon be born.

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Deserted by her husband, who teaches in a bucolic, private school for the visually impaired, Candida is a 50-ish, unemployed woman, estranged from her three daughters, at least two of whom blame her for the failure of her marriage. To the astonishment of everyone in her sphere, she embarks on a completely new, though modest life in a tiny, walkup flat in one of London's immigrant communities. Her consciously passive efforts to find new friends and discard old ones leads her to keep a diary, to take a night course on Virgil, and improbably--when the night school closes--to join the Health club that replaces it.

Eventually, she assembles six new friends--the seven sisters--for an Aeneas-like journey from Carthage to Rome, with plans to consult the Cumean Sybil en route. Illness draws her closer to her middle daughter, Ellen, whose own perspectives on her parents' marriage contrast with those of her mother. Illness also forces an abrupt end to the travels. Candida wrestles with the issues of survival, suicide, and the meaning of life for an aging woman in an aging body whose entire purpose had once been helpmeet and mother. Can any other purpose be found?

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One April day, a middle-aged writer, who was raised a Protestant but is not religious, is surprised to find a stranger, wearing a plain raincoat, in her home. The intruder says that she is Mary, mother of God, and something in her direct simplicity announces the truth of her claim. May will be the busiest of Mary's year, and she is tired; she asks to stay for a week to rest. Over lunch of soup and sandwiches, the two women establish an arrangement that Mary will stay and that if her host chooses to write about the visit, she will call it a work of fiction.

As Mary quietly goes about a banal existence--shopping, napping, doing laundry, using the toilet--the writer embarks on an investigation of Marian history--contrasting the relatively few biblical references to the mother of Jesus with her enormous fame and heavy responsibilities over two thousand years. Why has Mary been venerated? How can she cope with the thousands of prayers sent to her each day? Can transcendence reside in the mundane tasks of female life?

By the time her guest leaves, the writer is not converted but she comes to the conclusion that faith includes the acceptance of uncertainty, and that writing is an act of faith.

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Written as an interior monologue, Destiny begins as Chris Burton receives a phone call informing him of his schizophrenic son's suicide. Burton, a British ex-pat journalist in the final stages of writing his chef d'oeuvre--a cultural history on national character--is married to Mara, a provocative, capricious, flamboyant Italian. The vitriolic arguments and hurtful stratagems that characterize their discordant marriage intensify with the crisis of death and its aftermath--the identification, transport and entombment of Marco's body. Family relationships are further complicated by Mara's distrust and estrangement of her adopted daughter, Paola.

Burton reveals the chaos that schizophrenia imposes not only on the patient, but also on the entire family. In order to avoid prison following an attack on his family and home, Marco had been placed in a psychiatric institute, Villa Serena, and it was at this facility that Marco stabbed himself to death with a screwdriver. The onset of disordered thinking and erratic behavior, the search for therapies, the various repercussions of guilt and blame (including recriminations about the intense, border-blurring maternal love lavished on Marco), are re-examined by Burton as he travels from London to Rome, sits vigil by his son's body in the camera ardente, and confronts his wife at her family's tomb.

Burton's physical distress mirrors his mental anguish. Burton has heart disease and obsesses about lacking his anti-coagulant medication. In addition to the worry of clot formation, urinary retention prevents Burton from emptying his bladder. These physical ailments of containment, confinement, obstruction and blockage form resonances throughout the book: the tomb, the strictures of marriage and the leakage of adultery, the oppressive family 'house of ghosts,' the separateness of interior thought from observable behavior, the barriers of language, the herky-jerky redirections of emergency travel.

Furthermore, the will to create permanence, to make one's destiny more than a transient destination, informs Burton's moves. In the midst of his exploding marriage and tormented trek home, Burton agitates over his work, and in particular, his book, which "must serve to transform a respectable career into a monument" (p. 1).

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Manlius is a 5th C Roman patrician living in Provence who has studied with the wise, reclusive Sophia. He writes his understanding of her teaching in his essay, 'Dream of Scipio,' which trades on an essay by the great Roman orator, Cicero. Sensing that the Empire is gravely threatened, he makes a pact with barbarians, sells out his neighbors, slays his adopted son, and becomes a bishop of the Christian religion, which he has long despised. Late in this ruthless and doomed attempt to salvage what he values most in his world, Sophia makes it clear that he has misunderstood her teaching.

Olivier is an astonishingly gifted 14th century Provencal poet whose intolerant father tries to stifle his love of letters, among which is Manlius's 'Dream'; his father destroys the manuscript, but Olivier recopies it from memory. As plague advances on their region, Olivier finds a mentor in the high churchman, Ceccani, who is bent on keeping the papacy in Avignon. He plans to destroy Jews as symbolic expiation for plague, widely construed to be a form of divine punishment. Olivier befriends a Jewish scholar and falls in love with his beautiful heretic servant.

The 'Dream' and the imprisonment of his friends lead Olivier to question and then betray his mentor. Either because of his efforts to save them, or for his role in a murder, he is mutilated--his tongue and hands cut off to rob him of speech and writing. The brutal mutilation appears early in the book--it is not fully explained until the end.

Julien is a French historian who has studied the poet, Olivier, and the rendition of Manlius' manuscript. He finds solace in his erudition as his county falls to the Nazi occupation. An old school friend who is a collaborator, gives him work as a censor and tolerates Julien's Jewish lover, the artist Julia. In the end, Julien is forced to choose between saving either another school friend in the Resistance or Julia. He chooses Julia, looses her anyway, and commits suicide in a vain attempt to warn his friend.

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A child dies in the hospital shortly after the infectious disease consultant, Dr. Michael Grant, evaluates her. The 35-year-old physician has cause to be troubled by the patient's death. He failed to perform a careful examination, did not check the results of her most recent lab tests, and held off on ordering antibiotics. Although an autopsy was not performed, it is believed she died of sepsis.

Divorced and recently relocated to North Carolina, Dr. Grant is already depressed. Now he must worry about the possibility of a malpractice lawsuit. Jonas Williams, the father of the dead child, is also ill. He complains of fatigue, visual disturbances, confusion, night sweats, and fever. Jonas has developed unusual lesions in his throat and retina--white threads in a serpentine pattern. A biopsy of his oral lesion demonstrates the presence of osteoblasts and new bone formation. Dr. Grant becomes convinced he has stumbled onto a completely new infectious illness even though he cannot identify the causative organism.

Jonas experiences gastrointestinal bleeding as a result of a low platelet count. He dies in a trailer that has caught on fire. Dr. Grant soon develops the same symptoms as his patient. He remembers coming into contact with some of Jonas's blood. He is admitted to the hospital with massive gastrointestinal bleeding. His physician attributes the bleeding to ulcers, gastritis, and thrombocytopenia. Dr. Grant, however, believes the bleeding is due to the same mysterious disease that Jonas had.

The body of Jonas's daughter is exhumed, and there is anatomic evidence of the same bizarre changes that occurred in her father. Dr. Grant visits a cabin in the woods where Jonas had lived. He is looking for clues to the puzzling new illness. What he finds, however, is not an answer. Instead, it is a renewed appreciation for his life as well as the world around him.

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This is the story of Siddalee Walker's desperate search to understand the life of her outrageous, melodramatic, beautiful, alcoholic mother, Vivi. Now a 40-year-old successful director, Sidda is estranged from Vivi because of a too-frank newspaper interview that characterized Vivi as a loving, outrageously creative, abusive mother. Putting her engagement on hold, Sidda hides away in a cabin in the northwest with the only thing her mother concedes in Sidda's efforts to make up: a scrapbook that chronicles Vivi's life with three other spirited Southern belle renegades, the Ya-Yas.

Thus, the story unfolds with scrapbook versions of Vivi's rigid Catholic upbringing and the beginnings of the Ya-Ya sisterhood, through their adolescence and bayou debutante years, through their marriages and mothering the Petites Ya-Yas. Living her mother's life through the scrapbook and with a little help from the now 60-something Ya-Yas, Sidda comes to understand her mother's character with all its lavish, passionate, sorrowful, and always humorous dimensions.

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Ruth is an orphaned seamstress. One day, while repairing ladies' dresses at a ball, she meets Henry Bellingham, an aristocratic young man who accompanies his proud partner to the seamstress' room. Circumstances throw Henry and Ruth together and the two become close friends; innocent Ruth has no idea of the trouble into which this affair is leading.

Henry invites her one Sunday to walk with him out of town to her old family home. She is blissfully happy during the trip, but on their return, they are overtaken by Ruth's employer who jumps to conclusions about the couple and fires Ruth on the spot. Pressed by circumstances, Ruth accepts Henry's offer of help. She travels with him to Scotland and the two become lovers. While in Scotland, Henry becomes ill. His mother is called and as soon as her son is well he returns to London with her, leaving the disgraced Ruth behind.

Ruth is ready to kill herself but is stopped by Thurston Benson, an invalid who pities Ruth and finds her a place to stay as she falls ill in her despair. When Thurston and his sister Faith find out that Ruth is pregnant, they have her move in with them, presenting her to their friends as a widow. Ruth bears a son and everything goes well for many years. Ruth's piety and goodness win the respect of her very traditional neighbors.

About this time, Henry Bellingham is campaigning to represent the district in which Ruth lives. He recognizes Ruth and tries to win her again, even offering marriage, but she will not listen to him. Soon after, a jealous woman in the town discovers Ruth's secret. Ruth is fired from her position as governess and despised by the townspeople. All her goodness stands for nothing in the face of her early mistake.

Ruth struggles on for her child's sake, even helping in the hospital during a typhus epidemic. She learns that Bellingham is nearby, deathly ill from typhus. She helps cure him, but leaves his bedside before he can recognize her. She, however, contracts the disease and dies. Bellingham comes to see her body.

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In 1768 the young, feeble-minded King Christian VII of Denmark sets off on a prolonged tour of European capitals. His "handlers" determine that he needs to have a doctor along to help fend off, and to treat, the King’s frequent bouts of "agitation." Therefore, they appoint Johann Friedrich Struensee, a German physician from Altona, as the Royal Physician. Christian and Struensee develop a close bond; when the trip is over, the Royal Physician stays with the King and becomes a permanent fixture at the Danish court.

Christian is unstable and childlike. He enjoys playing games, but is totally uninterested in his beautiful young English wife, Caroline Mathilde. She becomes pregnant the first time he visits her, but he never sleeps with her again. Meanwhile, the King’s ministers actually run the government, even though he is theoretically an absolute monarch.

When Struensee, who is an Enlightenment intellectual, enters this ménage, he decides to reform the State by getting King Christian to agree to a series of enlightened new laws. Having won the King’s ear, the Royal Physician proceeds to rule Denmark for several years and to institute many of the reforms proposed by Voltaire and the other Enlightenment philosophers. Struensee also begins a tender, prolonged, and obvious love affair with the queen, who subsequently bears him a daughter.

The end of this story is not difficult to predict. Aggrieved members of the aristocracy manipulate the king to strip Dr. Struensee of his power and have him executed for adultery with Queen Caroline. She and the baby girl are shipped back to her home in England. The new Prime Minister retracts all of the reforms enacted by Struensee. And the demented king lives on in the fiction of his absolute power.

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Henry Moss is a medical geneticist specializing in Hickman syndrome, a fictitious disease resembling progeria. Children with Hickman syndrome experience premature aging and invariably die before the age of twenty. The physician meets Thomas Benhamouda, a teenager who genetically has Hickman syndrome but astonishingly has no physical manifestations of the disease. Dr. Moss identifies a protein that "corrects" Hickman syndrome in the blood of Thomas and proceeds to synthesize it.

Dr. Moss violates medical ethics by administering the experimental enzyme to his favorite Hickman patient, William Durbin, a dying 14-year-old boy. It is a last-ditch effort to save William's life even though the substance has not been tested for safety or efficacy in human beings. Dr. Moss also injects himself with the enzyme. He realizes the tremendous potential the drug has not only in curing Hickman syndrome but also in extending longevity in normal individuals. He is well aware of the great financial rewards he might reap from his discovery.

After a series of injections, William's deteriorating health stabilizes and even improves but he dies in his home. Dr. Moss has failed to save the doomed boy but in the process of breaking the rules and risking his career has learned how to understand and appreciate his own life as well as reconnect with his family.

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