Showing 211 - 220 of 468 annotations tagged with the keyword "Time"
In 1996, at the age of 31, David Biro is preparing for his specialty examinations in dermatology and is set to share a practice with his father. But he develops a visual disturbance. After repeated testing, he is found to have the rare blood disorder of paroxysmal nocturnal hemoglobinuria. The diagnosis was problematic, but the treatment choices are overwhelming. His youngest sister is a suitable donor, and he opts for a bone marrow transplant. He realizes that his decision was influenced not only by the diagnosis, but also by his personality and his reaction to the physicians.
Advance preparations are hectic and sometimes comic, especially his deposits at a local sperm bank. The pain of the transplant and the six weeks imprisonment in a small hospital room are told in graphic detail. The athletically inclined doctor suffers many complications: exquisitely painful ulcers of the scrotum, mouth, and esophagus; inflammation of the liver; unexplained fever; drug-induced delirium; weakness and weight loss.
His parents, sisters and friends leap into action to provide round-the-clock presence, but his independent wife, Daniella, resents the invasion. While David’s body is wracked with drugs and radiation, his family and his marriage are subjected to destructive forces too. Yet all--body, family, and marriage--emerge intact, though changed, by their experience.
Summary:In the heart of New York City the narrator comes across a tall, Senegalese man "speaking to a piece of chalk." The man is "neatly dressed / in the remnants of two blue suits . . . " and regal in his bearing. The man’s language is French, and he speaks "so slowly and precisely" that the narrator, no longer young, is reminded of his high school French class. He is also reminded of writing his name on the blackboard after returning to school, following his father’s death. The man knows "the whole history of chalk"; he knows "what creatures had given / their spines to become the dust time / pressed into these perfect cones . . . " The narrator knows that they are both elderly men "sharing the final poem of chalk . . . " [58 lines]
This lively volume of medical history chronicles the forms of suffering, illness, injury, and treatment endured by the members of the Lewis and Clark expedition of 1805. Beginning with three chapters of political and medical history to set the context, the story follows the adventures of the extraordinarily fortunate "Corps of Discovery" among whom Lewis was the most trained in the medicine of the time (having studied in preparation for the trip under Dr. Benjamin Rush of Philadelphia), and he only an amateur. Even professional medicine of the time was approximate and largely ineffectual, limited mostly to purgatives, opiates and laudanum for pain relief, bleeding, and topical applications of various compounds or herbal substances.
The story chronicles the main events of the trip based on the extensive journals of Lewis and Clark as well as other historical account, maintaining focus in each chapter on the medical incidents including gastrointestinal distress from parasites and contaminated water; effects of overexposure like hypothermia and exhaustion; infections from wounds and scratches; syphilis; dislocations; muscular spasms; mosquitoes and other insect bites; snakebites and other animal attacks.
Along the way Peck pauses to explain the rather rudimentary medical theories upon which treatments were based, the effects of particular known treatments, and what Lewis and others likely knew, guessed at, or didn’t understand about lead, mercury, opium, and certain herbal substances they used. He speculates about the contexts of their medical decisions and offers occasional contemporary analogies to help readers imagine the circumstances and tradeoffs the explorers faced.
Miss Rosie is homeless, a street person surrounded by her foul-smelling possessions. She is not a stranger to the narrator, who has thought long and hard about her present circumstances and how she might have been long ago before she became a familiar sight in the neighborhood. Now reduced to rags, this "wet brown bag of a woman," says the narrator, once was "the best looking gal in Georgia." The narrator "stand[s] up" for her through her "destruction."
The author selected 48 works of art, famous and obscure, which are presented in chronological order as full-page color plates. On the facing page of each piece is a brief essay which includes information such as artist, date and current location of the work. The essays, as well as the introduction by the author, are insightful, well-written, and demonstrate the author’s vast knowledge as a medical historian. Selections include the "Oath of Hippocrates", Studies of the Fetus by da Vinci, The Anatomy Lesson of Nicolaes Tulp by Rembrandt, The Dwarf Sebastian de Morra by Velazquez, "Muscle-Man from Vesalius" by van Calcar, and First Operation Under Ether by Hinckley (see art annotation in this database).
An Australian man has recently been diagnosed as having a fatal disease. He decides to take a quixotic trip to Europe, an open-ended adventure to unplanned destinations. This novel takes the form of 20 long and extraordinarily articulate letters written from Venice to an anonymous correspondent in Melbourne.
The letters work on three levels. First, they describe the writer’s travels from Locarno to Vicenza to Padua, stages of his journey prior to arriving in Venice. In fact, the book is divided into groups of letters, each of them dealing with one of the three cities and followed by a set of notes that illuminate some of the writer’s literary and historical allusions.
Second, the letters describe the writer’s current activities in Venice and especially his reflections on human nature and mortality. Finally, he refers back to events that occurred in Melbourne immediately preceding his journey. The most important of these events are the consultations with his doctor and, to a lesser extent, the reaction of Peter, his lover, to the lethal diagnosis.
Leonard Shelby (Guy Pearce) is trying to avenge the rape and murder of his wife. She was, as far as he can recall, killed by the same intruder who injured Leonard’s head, leaving him with "anterograde amnesia": he remembers everything up until the injury but no longer has short term memory. "I can’t make new memories. Everything fades."
Leonard’s single purpose now is to find and kill the person responsible for his wife’s death and his own disability. He remembers this purpose, and the steps in his progress towards it, by keeping annotated Polaroid photographs and tattooing important facts onto his body. At the end of the story--which is the beginning of the film--Leonard kills a man he believes to be the murderer, but who is probably not.
The story is narrated in reverse chronology, beginning with Leonard shooting the suspected killer, in short segments corresponding more or less to the length of Leonard’s ability to remember. These scenes are interspersed with parts of a longer scene that follows regular chronology, shot in black and white, in which Leonard sits in his motel room, talking on the telephone and telling the story of Sammy Jankis, a man he seems to remember from his earlier life as an insurance investigator.
Sammy suffered from anterograde amnesia after a car crash and Leonard dismissed his condition as psychological rather than physical, resulting in the refusal of Sammy’s insurance claim (the company doesn’t cover mental illness). Sammy’s diabetic wife, thinking that if the condition is mental it must also be voluntary, tries to get him to "snap out of it" by testing him in various ways: finally she tricks him into administering her insulin shot over and over until she dies. Sammy ends up institutionalized.
As we piece the story together, we realize that Leonard’s method for keeping track of his revenge plot is inadequate. Because the bits of information that substitute for memory can be manipulated, others are able to use him as an unwitting assassin. We also deduce that the story of Sammy Jankis may in fact be the story of Leonard Shelby, and that perhaps Leonard’s own wife was killed not by a murderer but by Leonard himself, the revenge motivation possibly planted by Teddy (possibly a cop) in order to make of Leonard a very efficient killer.
The story ends (where it begins) with Teddy’s plot turned against him by Natalie (Carrie-Anne Moss), a mysterious woman who has revenge motives of her own. Leonard takes Teddy (Joe Pantoliano) for the killer and shoots him. Our chilling realization is that Leonard will soon forget he has achieved his objective and again begin looking for someone to kill.
Anne (Sarah Polley) is 23 years old, is married with two small daughters, lives in a trailer in her mother’s yard, and works as a nightshift cleaner. She is diagnosed with advanced ovarian cancer and told she has no more than three months to live. She decides to tell no one that she is dying and makes a list of things to do in the time she has left.
She records birthday messages for her daughters, looks for a new wife for her husband (Scott Speedman), explores her troubled relationship with her mother (Deborah Harry), and has an affair with a man she meets in a laundromat (Mark Ruffalo). The last stages of her illness and her death are not shown; the focus is on how she chooses to live a life that has a new shape, both curtailed and illuminated by the knowledge of how soon it will end.
Hans Castorp makes a visit to the International Sanitarium Berghof in the Swiss Alps to rest and visit his cousin, Joachim Ziemssen. There he meets other patients from around Europe, all with different opinions about life and its meaning. Before his three week visit is up, Hans develops tuberculosis and ends up staying seven years. He leaves only when the Sanitarium gets news of the assassination of the Archduke that will begin World War One.
A doctor is riding through the desolate steppe at twilight and loses his way. He comes to a hut along the new railroad where two men, an engineer and his young assistant, are spending the night. After they all have a few drinks, the engineer marvels over the beauty of lights in the distance, while the young man says the lights remind him "of something long dead, that lived thousands of years ago." (p. 607) He sees no point in human love or accomplishment because, after all, we all have the same fate--death. This encourages the old engineer to tell a tale of his youth.
Once, when visiting his hometown on business, he had come across a childhood friend, a woman who was unhappily married. He looked forward to having a brief affair with her, but she considered him her savior. She desperately wanted him to take her away. The engineer agreed, but then callously abandoned her.
Later, he realized that "I had committed a crime as bad as murder." (p. 635) He went back and "besought Kisotchka’s forgiveness like a naughty boy and wept with her . . . " (p. 639) At the end of "Lights," the doctor rides off at sunrise toward home. All around him nature seems to be saying, "Yes, there’s no understanding anything in the world!"